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This apparent discrepancy in benfotiamine-elicited action on age formation and oxidative stress gsh-to-gssg ratio seems to indicate that other mechanism s may predominantly contribute to diabetes-induced oxidative stress and cardiac contractile dysfunction in current experimental setting.
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Part of these effects might be counteracted by benfotiamine, a liposoluble vitamin b 1 with much higher bioavailability than thiamine 24 .
The good news is that benfotiamine has been proven highly beneficial to those who are dealing with the chronic pain that is brought on by peripheral neuropathy.
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moreover, our results opens the possibility that benfotiamine might be useful in treatment of pathologies that involve chronic inflammation, observed in some neurodegenerative diseases, such as alzheimer s, parkinson s disease or multiple sclerosis.